From in vivo to in silico biology and back

In the interest of completing a thought that Andrew Torrance began earlier this week with his post, "Lexoinformatics," I'd like to share this item I encountered in BioLaw's feedcatching website, The Scientific Lawyer:

Barbara Di Ventura, Caroline Lemerle, Konstantinos Michalodimitrakis and Luis Serrano, From in vivo to in silico biology and back, 443 Nature 527-533 (5 October 2006) | doi:10.1038/nature05127:

The massive acquisition of data in molecular and cellular biology has led to the renaissance of an old topic: simulations of biological systems. Simulations, increasingly paired with experiments, are being successfully and routinely used by computational biologists to understand and predict the quantitative behaviour of complex systems, and to drive new experiments. Nevertheless, many experimentalists still consider simulations an esoteric discipline only for initiates. Suspicion towards simulations should dissipate as the limitations and advantages of their application are better appreciated, opening the door to their permanent adoption in everyday research.

Correspondence to: Luis Serrano, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Incidentally, the USDA holds an annual conference on biological systems simulation.